Is it safe to delete ~/Library/Caches/pip?

Rebuildable. Your tools make it again on their own. The cost is a slower next run.

What it is
Downloads pip has made and wheels it has built, kept so the next install doesn't fetch or build them again.
Made by
pip
If you remove it
The next pip install downloads packages again, and rebuilds any wheel it had built, slower, and it needs an internet connection. Installed packages are not touched.
How it comes back
Nothing to do, pip fills the cache again the next time it installs something.

The tool's own commands

The proof

Verified by
vendor documentation: pip documentation, “Caching”, section “Cache management” (https://pip.pypa.io/en/stable/topics/caching/), pip's own command “pip cache purge” clears every file from this cache. Recreation proved in a scratch PIP_CACHE_DIR on 10 Oct 2026 with pip 25.2: cache deleted, pip download filled it again.
Checked on
macOS 26.6.2, pip 25.2
Catalogue
Spaceific's rules.json 1.2.0, 2 Nov 2026. The whole file.

Related

Spaceific shows this rule for this folder in the app, checks it again at the moment you act, and moves only to the Trash, with Put Back. What Spaceific is.